Guanabana Cancer Cure
A Miracle Plant from the Amazon Region
Latin Name: Annona Muriaca
THE SANE HEALING SOLUTION and CANCER CURE SCIENTIFICALLY PROVEN!!!
“The time has come” – how many times we are hearing this sentence, nevertheless it is true because we are living in times of huge challenges changes and shifts where secrets of many different aspect of life are getting revealed to be known by the public – people also are more courageous to speak out what all should know and YES, if millions KNOW a fact, those who are hiding solutions, will have to surrender.
The biggest lie about Cancer Treatments and Chemo Therapy The Powers of Graviola (Guanabana in Brazil – Soursop USA) 1) Beats 12 kind of types of cancer such as Breast Cancer, Abdominal Cancer, Ovary Cancer, Uterus Cancer, Lung Cancer, Prostate Cancer, Boon Cancer, Pancreas Cancer, Skin Cancer, Blood Cancer (Leukemia), Bladder Cancer, Liver Cancer NO SIDE EFFECTS, NATURAL CURE !!! Salubrious way back to a healthy state 2) The Fruit contains a substance called ACETOGENIN that has been proven as 10.000 (ten thousand times) stronger as ACETOGENIN, the drug used for Chemo therapy all over the world with the result of 90% to 10% survivors only – a Bingo Game with the life of people in all nations because the cure is already known.
3) As it is a NUTRIENT it works from INSIDE OUT – eating up the cancer cells, any kind of viruses, bacteria etc. Nutrients have no side effects on our body!!! – unbelievable, miraculous, BUT TRUE (I had the honor to experience many people with cancer even in a very advanced state who were getting well with a Power Juice containing Graviola and there are 1000s in Latin America who had the chance to know about it since 9 years of applications. Solution, Real Cure and permanently heal without Chemo. In case that the doctors ordain Chemo this Special prepared Juice has the powers to protect the healthy cells from burning and allows just the cancer cells to be destroyed, no nausea, no hair loss, neither any other common side effects taking that power plant of healing simultaneously. MY mother would not be alive without Graviola.
It is TIME TO SHARE and to SHAKE the World of Cancer and to shift the 90% to 10% into a 10% to 90% of survivors !!!
here is the chance to learn about a fact that there is something that has the power to cure cancer, that it has been scientifically proven and that it has been hidden away from people because it comes from Mother Nature and can not be patented in any way.
General Information About the Plant:
Graviola is an ever green tree growing in the Amazon region of Brazil and in other countries that are touched by the Amazon Forest. It also grows in the tropical rainforest of North America. He grows up to 15 meter high covered with green, long and glossy leaves. His divine fruit is green sometimes a bit yellow shining, has the form of a human heart with a skin looking kind like a big cactus. Its white fruit flesh is eatable and people can buy it on the local Markets. The diameter of the fruit is 20 to 40 cm and local people are eating it out of the hand, the pulp is used to produce a refreshing sour-acid drink or as sorbet.
Indian Tribes Used Graviola as Medicine For Centuries
Graviola counts with a very long history in the tribal herbal natural medicine. There are Healing substances in every part of the plant: a part of the powerful effects of the fruit we find high effective substances in the leaves, the roots, the trunk, the bark and the seeds. Indian Tribes know about the value of that miraculous tree and they are using the different parts tor multiple and diverse diseases and health Imbalances. Some examples: In Brazil Roots, Trunk and leaves are used as sedative tee and against nervousness, in other Latin America countries as sedative and as heart tonic medium, also for Diabetes. The leave tee is also used for lever problems and mixed with olive oil it is used for Rheumatism, Arthritis and Osteoarthritis pain in Peru. In Brazil they prepare a mixture out of an immature fruit mixed with Olive oil as extern treatment against Arthritis and Rheumatism. Leaves are also used against Parasites in Brazil and against Catarrh in Peru. Fruit, Seeds and Leaves are applied against fever, all kind of parasites, worms, diarrhea, in Brazil also to help increasing the milk of women after giving birth. In other countries such as Haiti, West Indies and Jamaica are using Graviola as anti spasmodic, sedative, coughs and flu, as nerve strengthening tee, for asthma, hypertension and all kind of parasites, diarrhea and problems at childbirth.
Graviola and Science Cancer Research – Scientific Results on Graviola
The Graviola Fruit is already under research since the late 39 of last century – At that Time the science found out that the plant has components, natural principles and properties called “Annonacaeous Acetogenins”, natural chemicals that are confirmed to be highly effective against many kind of tumor cells with components that are found as toxins that kills the cancer cells in a very specific way. Simply spoken Graviola has components that are able to isolate every cancer cell, to build a kind of bubble around it avoiding that the cancer cell can get any further nutrient, so it dies. The dead cancer cells are eliminated by the own body system without any side effects. Those components are hidden in all parts of the tree and in different combination they are used for many different kind of disease. They are documented as anti-microbus, anti-parasitic, antitumorous, anti-cancerous, anti-depressive and anti-spasmodic. Several study results have been published but few people reacted.
Since 1976 profound researches of the National Cancer Institute of the USA resulted in curing an “Adenocarcinoma” of the large intestine after short time. The therapeutic effect confirmed the power of Graviola and her components. This powerful component has been discovered by the German Research Scientist and Oncologist Helmut Keller and with three more Scientists they realized many studies on Graviola. As the Plant does NOT ALLOW any chemical process without losing the healing powers never nobody got to know about this effective cancer treatment. WHY??? – because it only works in natural form and a plant cannot be patented in any form, so the Pharmaceutical World and the Monopoles could not get any profit from it and that is the reason they hided the information. Result: Graviola contains very active, cytotoxic effects against cancer cells with a chemo therapeutic power that is 10.000 x stronger as Adriamicin, the drug that is used for traditional Chemo Therapy, – without any kind of side effects!. (Since a while the HSI is offering now the copies of the results that can be bought for 25,00USD) After the confirmation that Graviola can cure naturally Cancer the National Health Institute has indicated 20 Labs to studies the plant during 20 years without any result to transform the active principles into a valid remedy. At the end they gave up and let the miraculous findings in the drawer of their institutes. Since 1996 other groups of scientists did researches on Graviola and found out that the fruit possesses characteristics against tumor formation and that it produces selective toxins against different kinds of cancer cells, without attacking healthy cells. They confirmed the findings of their results were published 8 different clinical studies. The different studies of different laboratories resulted in incredible findings that the Acetogenines of Graviola have an unbeatable component in prevention of enzyme formations, which are only found in the diaphragm by tumors and cancer cells. That is the reason, why they are poisonous only for cancer cells without attacking healthy cells. The Acetonines recognize the sick cells isolates the individual cancer cells and for missing nutrients the cancer cell dies. In the year 1997 a small group of scientists found out, that Graviola contains also alkaloids which have an anti-depressive effect. In the same year the PARDU UNIVERSITY published the information that they discovered even more powers within Graviola. Their clinical studies confirmed that the “Annonacae Acetonine” in Graviola are so effective, that they do not only kill normal cancer cells, but that they are also very effective in killing those cancer cells that are resistant on Chemo Therapy. This investigation explained how that is possible: Those cancer cells that survive the Chemo Therapy are developing resistance against many other kind of drugs, called Multi-DrugResistant (MDR) what makes them immune against any treatment and leads the patient 100% to death. After 20 Year of research the Pharma Industry got aware of the Plant and started research by their own seeking a form and way to transform the active principles and components into a cancer remedy. They also failed. Graviola does not allow any kind of chemical reproduction. It is reconfirmed that Graviola only works as it grows in nature and it beats cancer better then any synthetic drug or heavy poison rays. Until today many different groups of scientists are still researching to create a similar product as Annonacins and it still works only like it grown in Nature.
All that information has been kept in secret because Pharmacies could not transform it into something that would give them a huge profit. So they gave proof that they are not really interested in heal people but in making huge profits from those who are already sufficiently hidden by the disease itself. Why would somebody create so many unnecessary pain when there is something much stronger and without any life threatening side effect. At the end of the nineties one of the Scientists who was part of one of the research teams broke the silence for reasons of consciousness and some of the reports were accessible for the medicine world. Simultaneously some people from Brazil got kind of divine guidance to go to the Amazon and to study the Plants of the Rainforest. They were integrating the native people to learn from them as their knowledge about healing plants of the Rainforest is reaching back in time for many centuries. The good thing is that for one time in this world the science is NOT finding a way of manipulation – the power of healing cancer lies in Graviola and several further plants that God preserved to be used like the Almighty lets it grow. It is a blessing for Mankind and a gift from Mother Earth – A wake up call to become conscious and to start honoring the gifts we have forgotten that they exist. When we destroy the rainforests we destroy the lungs of our planet and without oxygen all life will die. We need to open up our hearts to understand that all what we experience has a solution and all what we suffer of different kind of disease has a natural way of cure in nature.
Nutritive Values of Graviola Minerals
Iron, potassium, calcium, copper, magnesium, manganese, sodium, phosphorus, sulfur, Selenium, zinc,
Vitamin A, Vitamin B1, Vitamin B2, Vitamin B3, Vitamin C
Dietary fibers, Tannin, Proteins, Lipides
Ethno-medical Uses of Graviola in different Tropical Countries and USA
Abscesses, Tumors, Edemas, Worms, all kind of Parasites, Bronchitis, Breathing Difficulties, Coughs, Diabetes, Digestive Imbalances, Dysentery, Intestine Parasites, the Intestinal/Colic Attacks, Fever, Liver Problems, Neuralgias, Nervousness, general Body Pain, Rheumatism, Tetanus Peru Tumors of all kind, Intern Ulcers, Parasites, Lice, Hypertension Diabetes, Dysentery, Indigestion, Inflammation, Flu, Liver Disorders, Spasms, Fever and as a Sedative Panama: Tumors, Ulcers, Parasites, Worms, Digestive Disorders (Dyspepsia), Diarrhea and Kidney Problems: Renal Insufficiency – Renal Failure Mexico: Tapeworm, Indigestion, Diarrhea, Dysentery, Fever, Chest Colds, Ringworm, Scurvy, Styptic (bleeding)
Colds, chills, fever, flu, diarrhea, indigestion, nervousness, palpitations, rash, spasms, skin disease, and as a sedative and calmative agent
Curacao: Gallbladder Problems, Nervousness, as a Sedative and Calmative Agent, Childbirth
Parasites, Lice, Flu, Digestive Sluggishness, Diarrhea, Fever, Coughs, Pain, Weakness, Wounds, Pellagra, Nervousness, Cardiopathy, Spasms, Sedative, Lactation Aid after Childbirth,
Parasites, Worms, Asthma, Fevers, Heart Disease, Hypertension, Lactation Aid after Childbirth, Nervousness, Sedative, Spasms, Tetanus, Water Retention and general Weakness,
Ringworms, Blood Cleaning Agent, Hypertension, Palpitations, Fainting, Insomnia, Lactation Aid after Childbirth, Flu,
Cancer, Tumors, Ulcers, Fungal Infections, Intestine Parasites, Hypertension, Depression
Asia – Malaysia
Furuncles, Coughs, Colds, Diarrhea, Dermatosis, Hypertension, Rheumatism, and to Reduce Bleeding British West Indies: Tumors, Intestine Parasites, Asthma, Childbirth, Lactation Aid, Hypertension
Cancer, Kidney Problems, Bladder Insufficiency, Liver Disorders, Dysentery, Malaria, Stomach Problems, Ringworm, Lice, Parasites, Childbirth, Asthma, Hypertension, Heart Disease, Arthritis, Scurvy and as a Sedative
After learning about ethnological medicine and their high evolved knowledge we should ask ourselves who is more advanced. They have no hospitals and they have NO CANCER or did you ever see a Native in a Cancer Department of a Hospital? They do not have Laboratories, they don’t transform any plant into a pill and they are heal. The Natives still show us today how to live with nature and how nature provides all what we need for a healthy life. What do we as the so called Civilized World with Nature and with ourselves? We allow destructive exploitation, depletion, exhaustive cultivation, robber economy, not only with Mother Nature but also with our own lives. We burn the candle at two ends disrespecting the holiness of our body. We abuse a maximum and the end is deadly disease. Is that a wonder? No it is just a consequence of our issues, our habits, our believe systems and our actions, of out thoughts, words and the ability to look away when things are not in harmony with the cosmic order. We just don’t care when it does not hit us personally. To heal really we have to heal ALL THE REALMS we are living in otherwise we only get a momentum cure. Can you feel that? It is NOT a question of understanding but of feeling!!!!! We shot our feelings down
You go against your feelings and you get sick!!!
How many times a day we do that?? We have to come back to the heart and stand up to safe the natural resources that are still intact like the rainforest as biggest source of healing plants that exists in our world. A German Doctor made holiday in the Amazon Region and he was wondering how many natural remedies are there on the market. He took some of the to try and as I started to teach in Germany about Graviola and the Rainforest he showed up and said: I am director of a Hospital and I was looking for a way to make people the Amazonian Healing Powers available. I our Hospital we have a new system and are open for alternative healing methods. We offer open Seminaries and you can come whenever you want to talk about cancer and other disease. I did for Diabetes ….. it was amazing So the Western Countries are learning about Graviola and the Healing Powers of Graviola, the miraculous fruit that brings never ending surprises to people with cancer and other heavy disease. Graviola is a chance for all those who are hidden by Cancer or one of the other diseases of civilization.
This Newsletter Is a Wake Up Call and a Chance to Survive Cancer
Graviola is not only a miracle against cancer cells but has also components (results of researches) that can eliminate other chemicals like cortisone, drugs and all kind poisons in our body. Graviola is the power of life that is able to clean all poisons we are exposed today in our daily life in air, water and nutrients. It has the amazing natural potency to clean and to regenerate our body cells.
CANCER “MAGIC BULLET” DISCOVERED – but drug giant hushes it up!
10,000 times stronger than chemotherapy with no adverse side effects DARYL S. HAD 12 TUMORS IN HIS PROSTATE. But he received a cutting-edge treatment that helped save his life. And… In 3 months, his PSA dropped AND THE TUMORS DISAPPEARED HOW? Daryl’s secret was the help of an amazing tree that grows deep in the Amazon rainforest. Called Graviola, it may well prove to be the ultimate cancer-fighter. Studies by the National Cancer Institute already show that Graviola extract is 10,000 times stronger than top chemotherapy drugs…
Yet it’s incredible precision hunts down cancer cells while leaving healthy cells completely alone! Graviola just seems to “know” which cells to kill and which to avoid. There’s no nausea, no hair loss, no weight loss, no weakening of the immune system. The news about Graviola sent shockwaves through HSI’s extensive medical network. But the story behind Graviola is just as shocking. As we learned, this lifesaving discovery was very nearly denied to mankind. And I’m sorry to say the reason is that somebody sat on the research. The trail of evidence clearly shows…
For 7 long years, a billion-dollar drug company covered it up!
What’s more, this is undoubtedly not the first time that something like this has happened. Following is a textbook example of how modern drug research works and how your health falls victim to the pursuit of money and power: It all started in the early 1990s, when this well-known drug giant started pouring money into the search for a cancer cure… What gave Jacqueline the power to CONQUER BREAST CANCER? JACQUELINE HAD BREAST CANCER, but she also had a huge advantage in her battle. Best of all, it works by using your own body’s army of natural “killer cells.” So, it actually makes you feel more energetic, rather than sapping your strength. Like many such firms, they were intrigued by the healing powers of rainforest plants. They discovered that Graviola was being used by Amazon Indians to treat a huge range of diseases. And when they tested its cancer-fighting powers, bingo, they discovered a revolution… But you can’t make megabucks from any cure UNLESS YOU PATENT IT… And no one can patent a tree that’s been around for millions of years. So the drug firm tried for seven years to come up with man-made duplicates. But they hit a brick wall. Try as they might, they couldn’t match Mother Nature. Finally, they tossed in the towel… Okay, they’re in business to make money. Fine. But let me ask you… If the research files for this breakthrough were sitting on your desk, what would you do with them? Call a news conference? Send out press releases? At the very least, wouldn’t you publish them all in a prominent medical journal? After all, more than 6 million Americans have died from cancer in the last few decades. Think how many might have been saved if a discovery like this had been available. But, instead of turning it over to independent researchers…….They boxed it up, put it on the shelf – AND TURNED OFF THE LIGHT Happily, one courageous researcher just couldn’t live with that decision. He spilled the beans… and the result may turn out to be the most life-saving substance on earth. More clinical trials are needed, but more than 20 studies to date have already established that… Graviola can wipe out 12 types of cancer cells, including breast, prostate, colon, lung and pancreatic tumors Yet, unlike any chemotherapy drug, it leaves healthy cells undamaged. A miracle? Perhaps. Yet even now, not one drug company we know of has picked it up and run with it. WHY? Same reason. No one can legally patent it.
Are you starting to see? AMAZON MIRACLE TREE fights much more than cancer While scientific research on Graviola has focused on its cancer-fighting powers, the tree has been used for centuries by tribal healers to treat an astonishing array of diseases, hypertension ringworm, muscle spasm, scurvy, insomnia, dysentery, flu, rheumatism, diarrhea, neuralgia, malaria, rashes, arthritis.
Healings, Cures and Lies About Conventional Treatments
True example: In Germany one of the Patients of Dr. D. Hamer (working on the psychic shocks for cancer cure) suffered breast Cancer and she was asked three times in the hospital if she is Jewish and she denied – she had family members who were but she wasn’t. She was wondering first why they asked that. The next day another doctor appeared in her Hospital room offering her a heavy treatment apart of the chemo therapy and he told her that people with cancer have only 10% chances to survive but she could be one of the 10% when she would accept this incredible expensive proposal. The got aware of why she was asked if she is Jewish and as it was not the same doctor, she answered, sorry I cannot do that as I am Jewish – the doctor replied: oh I didn’t know and leaving the room he remarked: you will be fine anyway… can you believe that? But that is the truth about heavy and expensive treatments and people believe the Chemo (90% are not making it) and suffer for nothing…. The Lady reported the doctors and left the hospital. One thing is the big lie about Cancer – the other side has the solution and is not sufficiently known yet to help many people and children avoiding so much unnecessary pain. You will become porter of the secret – during May I will send out a report about the plant and how to get the juice product that is saving 1000s of lives since 9 years in Latin America and 5 other countries – not in USA yet apart of some friends of mine I sent the product to help them get well. (She is German and the report is to find on Dr Hamer’s German Website)
What more can I say now as that I have experiences with Graviola since 7 years – As I learned by guidance how cases are set into motion that ends up in heavy disease or chronicle disease, even aids is one of the biggest lies, during this year I will publish more reports on products and natural powers for many of diseases that are used by the science to as a good income instead to inform about simple cures from inside out. Graviola helps reproducing the killer cells without our body that is the reason self defense it growing fast as the own body helps the nutrients to fight the sick cells in the body structure -any of them. The latest studies in Brazil have confirmed that the product combination with Graviola has a component that kills even the Hospital Virus – this is a killer virus without cure until today that is 1000% deadly – we got results that are amazing. In the meanwhile the component who does that that been found. We are working to get information out to doctors and alternative healers. There is so much to learn and to do because the greatest shift has to be done in education. It is not easy to
teach people who have been driven in only one direction to believe denying all other ways,even if their own life depends on that. The reason of cancer is a psychic shock and it is not so difficult to learn about it – recreate your life from inside out and use the fruits, plants and natural elements that Mother Earth grows so we can get well. Let’s open our hearts and minds for the Amazon Rainforest and join people work fro the protection of this last wonder of an intact ecosystem and stop burning down 5000 square miles each day so some people can make their profit. They are killing life itself and we are the crown of creation and should honor all LIFE in first place as holy!!!! Healing of cancer is possible knowing about the cause of self creation and with the help of Mother Earth Cancer has no chance !!!!! Soon I will do some webinars on the topic and you will be informed……
Information about Graviola and the power products and where to get them:
Info: firstname.lastname@example.org For automatic news – sign up for the free newsletter and email teachings at: www.2thepowerofspirit6.com/sq more about my work: www.2thepowerofspirit6.com If you want to help people get well inform your family members, your friends, your colleagues, your associations, your communities you can share that report…..; it is time to stop monopoles and manipulations. It is time to honor life and to love the fellow as ourselves…….. GRAVIOLA HAS THE POWER TO PREVENT and it is just a fruit in the Garden of Life GRAVIOLA is reproduced in plantations to let the Rainforest intact……
Blessings and time for reflection And don’t forget: Miracles of life are there for everybody Regina E.H.Ariel
The Guanabana Tree Cancer Cure
Studies show that a certain species of tree is practically a neighborhood pharmacy when you look at all the things it can do. Scroll down and find out!
- The bark has properties powerful enough to fight the most fearsome fungus…
- The unripe fruit has been used to treat diarrhea and dysentery…
- The leaves, roots and stem have been shown to clobber in bacteria grown in lab cultures…
- The plant seeds are known to send parasites packing…
- The root bark has been used to tame raging fevers…
- A leaf extract stood its ground against malaria…
And best of all—a 1976 National Cancer Institute plant screening declared that the leaves and stem of this remarkable plant could even poison and kill cancer cells naturally.
So what is it called? Well, it depends on who you ask!
In Brazil it’s called chirimoya… elsewhere in Latin America people call it guanábana… other people know it as soursop or custard apple… but in English, most people call it graviola.
This small, evergreen tree typically is found in the rainforests of Central and South America, Africa and Southeast Asia. The tree produces a large heart-shaped fruit with a yellow-green, prickly skin and white, fleshy fruit inside.
This is no ordinary fruit! Indigenous people have long understood and treasured graviola’s medicinal value. After the groundbreaking research of the National Cancer Institute, the Western world sat up and began to take note…
What makes graviola such a fierce cancer warrior?
In 1977, researchers at Purdue University used grant money from the National Cancer Institute to answer that question.
They narrowed down a group of plant chemicals in graviola called annonaceous acetogenins that seemed to pack a powerful punch. The in vitro (test tube) studies suggested the acetogenins had an amazing ability to inhibit cancer cells—while leaving healthy cells untouched.
Apparently, graviola plant chemicals can attach to tumor cells and stop them from reproducing. Eventually the acetogenins go in for the kill and wipe out the cancer cells!
Some critics of this natural wonder argue that in vitro studies don’t tell the whole story. They say we need in vivo studies (where real, live humans take the substance) to determine if it’s safe and effective.
Well, hold on to your hats! The July 2011 Journal of Nutrition and Cancer1 published study results conducted by researchers from Virginia Tech in Blacksburg, VA (near Cancer Defeated’s home offices, as it happens).
These scientists discovered that dietary graviola fruit extract (GFE) “selectively inhibited the growth” of breast cancer cells—both in lab cultures AND in live humans.
These findings fall right in step with a host of study results published by research groups in the U.S., China and India.
You should know that graviola isn’t the only plant that contains the acetogenin cancer warriors. In fact, some research about acetogenins focuses on those from another plant…
Graviola’s got a cousin named Pawpaw!
I’m talking about a remedy we featured in Issue #53: the pawpaw tree. You don’t have to go to the rainforest to find this one. It’s native to eastern North America and produces the area’s largest edible fruit. You can view this back issue and others by visiting our issue archive at www.cancerdefeatedpublications.com/newsletters
Native Americans and early settlers used the tough inner bark of the pawpaw tree to make ropes, fishing nets, and mats. The bark, leaves and twigs also contain natural insecticides that can be used to make organic pesticides.
As a Professor of Pharmacognosy at Purdue University, Dr. Jerry McLaughlin spent over 20 years studying the pawpaw tree. He found that there were differences in the potency of trees based on their geographical location. (In case you were wondering, pharmacognosy is the study of medicines that come from natural sources.)
Dr. McLaughlin learned that the highest concentrations and most powerful acetogenins were in the Asimina triloba species of the pawpaw. These acetogenins drastically reduce ATP energy produced by cancer cells.
Without sufficient energy—the cancer cells eventually choke and die!
Dr. McLaughlin’s research uncovered 50 acetogenins in pawpaw, compared to 30 found in graviola. Further, he discovered a ‘double-ring’ chemical structure in pawpaw as opposed to a weaker single ring chemical structure in graviola.
Based on his findings, Dr. McLaughlin developed a procedure to standardize pawpaw extracts containing a certain amount of acetogenins, and licensed it to a company in Utah.
There are several companies that offer graviola and pawpaw herbal supplements through online and retail stores. Be sure to consult a medical practitioner if you want to include either nutrient as part of a cancer treatment regimen.
In any case, despite the funny names—these herbs are shaping up to be some top-notch natural cancer killers!
Footnotes Article #1:
1 Dai Y, Hogan S, Schmelz EM, Ju YH, Canning C, Zhou K. Selective Growth Inhibition of Human Breast Cancer Cells by Graviola Fruit Extract In Vitro and In Vivo Involving Downregulation of EGFR Expression. Nutr Cancer. 2011 Jul;63(5):795-801. Epub 2011 Jun 22. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/21767082