Grape Seed Extract

GRAPE SEED EXTRACT

grape-seed

Grape seed extract significantly inhibited the growth of colorectal tumors in both laboratory cell cultures and in mice, U.S. researchers report. A team from the University of Colorado Health Sciences Center in Denver says mice given the extract displayed a 44 percent reduction in the size of advanced colorectal tumors. The researchers also determined how grape seed extract works to inhibit cancer growth. It does so by increasing the availability of a protein (Cip1/p21) in tumors that “freezes” the cell cycle, causing cancer cells to self-destruct.

Using a commercially available grape seed extract, researchers exposed leukemia cells to the extract in different doses and found the marked effect in causing apoptosis in these cells at one of the higher doses. They also discovered that the extract does not affect normal cells, although they don’t know why.

The skin of red grapes is also loaded with other anti-oxidants, most notably Resveratrol, whose benefits also contribute to lowering other risk factors for heart disease such as the oxidation of LDL cholesterol.

http://www.eurekalert.org/pub_releases/2008-12/aafc-gse122208.php

http://clincancerres.aacrjournals.org/content/15/1/140.full.pdf+html